CHICAGO (AP) — Tyler Flowers hit a tying homer and Dewayne Wise delivered a go-ahead RBI single in Chicago’s two-run sixth inning, lifting the White Sox to a 5-4 victory over the Seattle Mariners on Saturday night for their fifth straight win.

Seattle took a quick first-inning lead on Kyle Seager’s three-run homer before the White Sox rallied to preserve their 2½-game lead over second-place Detroit in the AL Central. Seager also connected in the ninth against closer Addison Reed to get the Mariners to within a run.

Flowers, who entered in the third when starting catcher A.J. Pierzynski and manager Robin Ventura were ejected, led off the sixth with his fifth homer of the season — a drive to center on the first pitch of the inning by Blake Beavan.

With two down and Alexei Ramirez on third, Wise singled to center against off Charlie Furbush.

Pierzynski was ejected for apparently arguing balls and strikes with one out in the top of the third. When Ventura charged out of the dugout to protest, he also was ejected and had to be separated from plate umpire Lance Barrett by third base umpire and crew chief Jim Joyce.

After an exchange of several minutes, a livid Ventura left and Flowers took over behind the plate for Pierzynski.

Nate Jones (6-0) got the final out of the sixth to get the win. Reed gave up Seager’s 15th homer and then a single to Justin Smoak before getting the final out for his 24th save in 28 chances.

Reed blew a save Friday night when Seattle scored six times in the ninth only to get the win when Chicago rallied in the bottom half.

The Mariners loaded the bases in the seventh off Matt Thornton on a single, hit batsman and a walk. Brett Myers relieved and retired pinch-hitter John Jaso on a soft liner to second baseman Gordon Beckham to end the inning.

Chicago added an important run in the eighth on Alex Rios’ double, a bunt single by Flowers and Ramirez’s sacrifice fly.

Chicago starter Jose Quintana was wild in the first inning, issuing four walks. Dustin Ackley beat out an infield single to lead off and Trayvon Robinson walked. One out later, Seager hit a drive to deep right-center.

Quintana then walked the bases loaded before getting Brendan Ryan to fly out to end the inning.

The White Sox got one back in the first on Paul Konerko’s RBI single and another in the third on a run-scoring single by Rios.

And Quintana settled in after his shaky start, retiring 12 straight at one point. He made it through 5 2-3 innings, giving up five hits and three runs with four walks and four strikeouts.

Beavan (8-8), who was the losing pitcher in April when Phil Humber pitched a perfect game in Seattle for the White Sox, went five-plus innings, giving up seven hits and four runs.

NOTES: Mariners OF Michael Saunders, who collided with Eric Thames on Konerko’s winning single Friday night, was out of the lineup with a sore groin. Thames also was out but not because he was injured. He didn’t start with the lefty Quintana on the mound. He had a pinch-hit single in the eighth. … White Sox LF Dayan Viciedo was scratched with a sore right shoulder. … Ventura’s ejection was his third in his first season as manager. … The White Sox are 23-4 against the Mariners since the start of the 2010 season.

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