UPDATED 09/04/12 10:46 a.m.

CHICAGO (CBS) — At least 33 people were shot – three of them fatally – around the city over the Labor Day holiday weekend.

In addition, one person was killed and three others were wounded when they allegedly pointed weapons or opened fire at police, prompting officers to return fire.

The first deadly shooting happened early Sunday. A 38-year-old man identified as Jeffrey Smith was found slumped over the wheel of his vehicle, dead of multiple gunshot wounds, in the 9200 block of South Chappel Avenue near Warren Elementary School, about 3 a.m. that day.

Smith, of the 5100 block of South Marshfield Avenue, was dead at the scene.

Around 5 a.m. Sunday, a 45-year-old woman was found shot and stabbed to death in an apartment in the Uptown neighborhood. Around 5 a.m., Yolanda Holmes, 45, was found in her apartment in the 1000 block of West Montrose Avenue, according to the Cook County Medical Examiner’s office.

A man with lacerations to his face was also in the apartment, police said. He was taken in stable condition to Weiss Memorial Hospital.

Holmes operated a beauty salon in Uptown, and resided in an apartment in the Wilson Yard development, a low-income housing complex on Montrose Avenue near Broadway. After the popular Target store a block north on Broadway, Holmes was quoted in the Local Initiatives Support Coalition’s “Working Capital” newsletter as hoping her business would prosper “because of the people Target will attract.”

Finally, a 27-year-old man was shot in the neck and shoulders outside his home in the 5300 block of South Hamlin Avenue about 2:27 a.m. Tuesday, by someone inside a passing vehicle.

Eduardo Acosta was pronounced dead at the scene at 2:35 a.m., according to the Medical Examiner’s office. The shooting appeared to be gang-related, according to police, who were searching for a dark-colored sedan believed to be involved.

In the non-fatal shootings:

• A 39-year-old man was wounded while standing on the sidewalk in the 1000 block of West Hollywood Avenue – a stretch where thousands of commuters head to and from Lake Shore Drive night and day.

The man suffered a gunshot wound to the right ankle and was taken to Saint Francis Hospital in Evanston, where he was listed in good condition, police said.

• A gunman opened fire at a group early Sunday in the Belmont-Cragin neighborhood, critically wounding one man in the apparently gang-related shooting.

The 22-year-old victim was standing with the group of people about 1:35 a.m. in the 5000 block of West Montana Street when the gunman started shooting, police said. He was shot multiple times in the chest and was in critical condition at Advocate Illinois Masonic Medical Center. Authorities said the attack appears to be gang-related.

• A 25-year-old man leaving a bar in the River North area early Saturday was shot when a suspect on a bicycle attempted to rob him, police said.

The man was leaving a bar in the 700 block of North Franklin Street at 3:15 a.m. when a male on a bicycle approached and announced a robbery, police News Affairs Officer Amina Greer said. The suspect then shot the man and fled on the bike but didn’t get anything from the man, who was taken in good condition to Northwestern Memorial Hospital with a gunshot wound to the leg.

• About 4 a.m. Saturday, a man was shot in the West Town neighborhood. The victim, in his 20s, was shot in the abdomen in the 1100 block of North Western Avenue, according to police. He was in “stable” condition at John H. Stroger Jr. Hospital of Cook County, police said.

• About 10:40 p.m. on Friday, a man and a woman were shot during an argument on the Near West Side. They were in the 100 block of North Damen Avenue at 10:42 p.m. when they got into an argument with an unknown male, who took out a handgun and opened fire in their direction, police said.

Both the man, 23, and the woman, 25, were shot in the leg and taken to Stroger Hospital in stable condition, police said. The woman suffered gunshot wounds to both legs, police said.

The shooting happened a couple blocks from the United Center and close to the Suder Montessori Magnet School at Washington Boulevard and Damen Avenue. The male victim has a gang affiliation and a criminal record, according to a law enforcement source.

In incidents involving police, a suspect was shot and killed by officers just after 3 a.m. Tuesday near 74th and State streets.

The suspect was pronounced dead following the shooting. No officers were wounded, authorities said.

Earlier, officers shot and wounded a 17-year-old boy on 90th Street between Union and Lowe avenues, after he pulled pointed a gun at one officer, and began firing at another officer even after the first officer shot him down.

The suspect was taken to Advocate Christ Medical Center in Oak Lawn with several gunshot wounds, Chicago Fraternal Order of Police spokesman Pat Camden said. His condition was not known.

The Sun-Times Media Wire contributed to this report.

(Source: Sun-Times Media Wire © Chicago Sun-Times 2012. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.)