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Cubs Mark 100th Loss

Darwin Barney #15 of the Chicago Cubs forces out Brett Wallace #29 of the Houston Astros in the seventh inning on October 1, 2012 at Wrigley Field in Chicago, Illinois. (Photo by David Banks/Getty Images)

Darwin Barney #15 of the Chicago Cubs forces out Brett Wallace #29 of the Houston Astros in the seventh inning on October 1, 2012 at Wrigley Field in Chicago, Illinois. (Photo by David Banks/Getty Images)

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CHICAGO (AP) — The Chicago Cubs got their 100th loss of the season when Lucas Harrell threw six shutout innings to lead the Houston Astros to a 3-0 win Monday night.

Four Houston pitchers combined on a two-hitter and Fernando Martinez homered for the third consecutive game. The Astros avoided their franchise-record 107th loss in the opener of their final series in the National League before they move to the American League next season.

The Cubs lost 100 games in a season for the first time since 1966 and were shut out for the 14th time this season. Chicago has lost more than 99 games twice, setting the franchise record of 103 losses in 1962 and 1966. The Cubs have dropped 12 of their last 14.

Houston has matched its franchise record for losses with 106, but the Astros have won four of their last five and are 14-14 since Sept. 1.

(© Copyright 2012 The Associated Press. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.)