The outbound Bishop Ford was shut down following a police chase that apparently ended with an arrest on the highway.
The crash was reported about 10:25 p.m. near the steel bridge, about a mile south of East 130th Street, according to Fire Media Affairs.
The Bishop Ford Expressway remains closed Friday morning, one day after torrential rains pounded Chicago and the suburbs, dumping over five inches of rain.
One person was killed and two others were injured in a crash early Sunday on the Bishop Ford Expressway on the Far South Side, state police said.
A downstate man with a long criminal past has been charged in the death of a woman who was struck on the Bishop Ford Freeway.
An accident is causing major backups on the Bishop Ford Expy. on Tuesday morning.