The two, whose ages were not immediately known, were transported from the blaze to John H. Stroger Jr. Hospital of Cook County in serious condition.
One person was hospitalized after a fire broke out in a Michigan Avenue high-rise on Wednesday.
Residents at 3925 Triumvera Dr. were jolted awake when a fire started in a 9th floor condo after midnight.
A man was critically injured in a high-rise fire Sunday night in the North Side Lincoln Park neighborhood.
The two men who died in a South Shore high-rise fire had rescued an elderly woman from the blaze and returned to try to extinguish the flames.