UPDATED 01/11/11 12:33 p.m.

MERRILLVILLE, Ind. (CBS) — Interstate 65 reopened in both directions Tuesday afternoon, nearly two hours after multiple crashes forced Indiana State Police to shut the highway down in Boone County.

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Shortly before 10 a.m., the southbound lanes of I-65 were shut down at 109th because of a crash between a car and a semi, according to Indiana State Police Sgt. Ann Wojas. The backup southbound reached to U.S. 30, more than two miles.

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All lanes were reopened by about 10:40 a.m., but at about the same time, Indiana State Police advised drivers to stay away from I-65 in both directions near Lebanon — about 30 miles northwest of Indianapolis, due to multiple crashes. Police said several vehicles had slid off the roadway and a semi trailer truck had jack-knifed in Boone County.

I-65 was shut down in both directions between mile markers 140 and 143 in Boone County for nearly two hours as a result, but Wojas said those lanes were re-opened by about 12:30 p.m.

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The Sun-Times Media Wire contributed to this report.